When we talk about poly-drug use, we mean the combination of different substances. The problem with this is that the effects can reinforce each other, and you lose control of the effect. We would like to give you a brief overview of which substances interact with each other and how you can protect yourself and your body from negative consequences.
Known combinations and their effect on the body and mind
Some combinations are better known than others, and therefore much is already known about how they work. Although drugs and intoxicating substances are often banned, use still takes place. It is therefore all the more important that the most important safer-use rules are observed. Also remember that medicines or substances such as poppers, which are not drugs, can have an influence on the effect of other substances. Below, we would like to introduce you to a number of combinations that are already known.
Poly-drug use with ecstasy – with many substances there are problems
The combination of MDMA and other substances can have various effects on the body. Alcohol is said to increase the euphoria of ecstasy, cannabis can lead to an increased empathic effect in the late phase. The combination of crystal and MDMA has a dissolving effect, it can take up to four weeks before you feel the effects of ecstasy again. A combination of cocaine and MDMA can be dangerous, as it puts more strain on the cardiovascular system. According to users, it can also lead to a kind of inner turmoil.
Absolute contraindications are the use of tricyclic antidepressants, serotonin reuptake inhibitors (SSRI) and beta-blockers. There is a risk of serotonin syndrome, which is life-threatening. Protease inhibitors, which are used in HIV therapy, must not be combined with MDMA. There is a risk of poisoning.
Cannabis and other substances – these effects are to be expected
Two substances that are often used together are alcohol and cannabis. This leads to reduced mental performance, and your reaction time also suffers. Nausea is a possible side effect, as is severe drowsiness. The combination of hash and psychogenic mushrooms carries the risk of psychosis if a corresponding disposition is present. The hallucinogenic effect is increased by cannabis, the same applies to the combination with LSD. Speed and cocaine can increase the euphoria caused by hash consumption, and cocaine can have a negative effect on the cardiovascular system.
Cocaine and the combination with substances – these risks exist
The effect of cocaine alone is described as so intense that combinations rarely occur. There are side effects when combining coke and alcohol, as the effect of the alcohol is reduced. There is a danger that you will drink too much and alcohol poisoning may result. In addition, this combination often brings reckless behaviour patterns to light, so that under the influence of the two substances you can get into trouble and dangerous situations. Combined with speed or energy drinks, there is a risk of cardiovascular overload when using coke.
Mixed use of liquid ecstasy – GHB carries a lot of risk potential
Liquid ecstasy is one of the newer party drugs and has a much stronger effect than classic MDMA. Dangers are not primarily to be found in combination with other intoxicants, but when consumed together with medicines and food. For example, the consumption of alcohol and GBH is associated with severe respiratory impairment. The simultaneous consumption of milk can lead to persistent vomiting. Opiates for pain relief must not be combined, as respiratory arrest may occur. Combinations with poppers are also toxic, especially if they are inhaled heavily and intensively. There is a risk of complete respiratory failure, which can lead to death. GHB and poppers also lower blood pressure on both sides, so that fainting is common.
Crystal/speed together with other substances – Caution is important
The use of crystal dissolves the effect of ecstasy. The resulting excess intake of party pills can cause the circulation to üoverload and collapse. A stronger crystal effect is to be expected in combination with cannabis. The combination with cocaine is dangerous for the circulation, as it puts a lot of strain on the heart. There is an absolute danger to life if you use MAO inhibitors (for the treatment of depression) or beta-blockers (blood pressure reducers) together with crystal.
LSD and psychogenic mushrooms – not all combinations are suitable
LSD and mushrooms are among the most popular hallucinogens and also play a major role in the microdosing scene. The greatest danger with psychogenic drugs is the activation of a latent psychosis. Horrortrips are also a compilation that is made more likely by the combination of speed and LSD. Mixed use between cannabis and LSD is considered a potential danger for the development of psychosis.
Safe consumption – these are the rules you need to know
Mixed use is common, especially among men, the rate of experimental users is very high. Especially ecstasy, cannabis and cocaine are mixed together, which increases the risk of side effects. If you have decided to combine two or more substances despite all the known risks, be sure to follow these safer-use tips for your own safety:
- Drink plenty of non-alcoholic beverages, preferably water, between drinks to help your kidneys and liver.
- Give your party companion information about which substances you have combined.
- Mix only if you have already gained experience with both types of intoxicants. In addition, always wait until the first substance has fully developed its effect.
- Inform yourself about the combination of drugs and substances if you regularly have to take medicines.
Conclusion: mixed use is becoming more and more common – think about your personal protection
The combination of several intoxicating substances is more popular than ever before, especially at rampant gay parties where people sniff, swallow and smoke. Before you use two drugs together, find a reliable companion who will be there for you in case of emergency. A safe location is extremely important for mixed use, so organise a place to sleep or a lift for after the party in advance. If you are unsure, do not use two substances at the same time and wait and see if one substance is not enough.